Fall in C-peptide during first 2 years from diagnosis: Evidence of at least two distinct phases from composite type 1 diabetes trialnet data
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Response to Comment on: Greenbaum et al. Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data. Diabetes 2012;61:2066–2073
We greatly appreciate the letter from Rios et al. (1) in which they report a lack of association between basal or glucagon-stimulated C-peptide and basophil counts in recently diagnosed type 1 diabetic patients followed for 1 year. This is precisely the type of analysis of other datasets that we hoped to stimulate with our article (2). We are currently evaluating whether the observations report...
متن کاملComment on: Greenbaum et al. Fall in C-Peptide During First 2 Years From Diagnosis: Evidence of at Least Two Distinct Phases From Composite Type 1 Diabetes TrialNet Data. Diabetes 2012;61:2066–2073
We read with interest the article recently published by Greenbaum et al. (1) describing the novel observation of the association of basophil count with change in C-peptide in recently diagnosed type 1 diabetes (T1D). The authors speculated that this association could be based on a compensatory attempt to deviate cells via interleukin-4 cytokine in the autoimmune response. In fact, by repeatedly...
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OBJECTIVE We aimed to describe the natural history of residual insulin secretion in Type 1 Diabetes TrialNet participants over 4 years from diagnosis and relate this to previously reported alternative clinical measures reflecting β-cell secretory function. RESEARCH DESIGN AND METHODS Data from 407 subjects from 5 TrialNet intervention studies were analyzed. All subjects had baseline stimulate...
متن کاملFall in C-Peptide During First 2 Years From Diagnosis
Interpretation of clinical trials to alter the decline in β-cell function after diagnosis of type 1 diabetes depends on a robust understanding of the natural history of disease. Combining data from the Type 1 Diabetes TrialNet studies, we describe the natural history of β-cell function from shortly after diagnosis through 2 years post study randomization, assess the degree of variability betwee...
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Background and Aims: The prevalence of latent autoimmune diabetes in adults (LADA) among diabetic patients is less recognized and underdiagnosed. The aim of this study was to determine the prevalence of LADA in type 2 diabetic patients and to compare the characteristics of these two groups in Torbat-e Heydarieh, Iran. Materials and Methods: Totally, 198 male and 277 female patients diagnosed ...
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